Hematoprotective and Nephroprotective Properties of Ethanolic Extract of Anthemis odontostephana Boiss in Streptozotocin-induced Diabetic Mice

Background: Certainly, the trend in the treatment of diabetes by ethnomedicinal plants which have fewer side effects than chemical drugs has enhanced. Anthemis odontostephana Boiss has been recently known as an antioxidant, antiflammatory, and antimicrobial agent. Objective: hematoprotective and nephroprotective properties of Anthemis odontostephana Boiss ethanolic extract (AOEE) on diabetic mice has been evaluated in the present study. Methods: In this study, 70 mice were used. Diabetes was experimentally induced by intraperitoneal injection of STZ (60 mg/kg) in 60 mice. After three days, they were divided randomly into 7 groups. Group I and II served as non-diabetic and untreated diabetic controls, respectively. Group III received 30 mg/kg glibenclamide orally. Groups IV, V, VI and VII were given 10, 30, 90 and 270 mg/kg, respectively of AOEE for 20 days orally. At 20th day, the mice were dissected and blood and Kidney samples of them collected for hematological and pathological parameters analysis. Results: Daily treatment of diabetic mice with several doses of AOEE especially AOEE270 significantly declined FBG levels and improved RBC, platelet and WBC parameters in comparison of untreated diabetic control. Also kidney of the treated diabetic mice with AOEE especially AOEE270 indicated significant improvement of the renal tissue compared to those of the untreated diabetic mice. Conclusion: According to the obtained results, all doses of AOEE especially AOEE270 can improve hematological parameters and FBG changes and inhibits from kidney damages in streptozotocin-induced diabetic mice. It appears that AOEE can be utilized for treatment of diabetic as an antidiabetic drug.